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GITR Rat anti-Mouse, PE, Clone: DTA-1, BD

Catalog No. BDB558119 Shop All BD Biosciences Products
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BDB558119 0.1 mg
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Catalog No. BDB558119 Supplier BD Biosciences Supplier No. 558119

Description

Rat Monoclonal Antibody

The DTA-1 antibody reacts with GITR [Glucocorticoid-induced Tumor necrosis factor (TNF) receptor family-Related], a 66-70kDa homodimer glycoprotein that is a member of the TNF receptor superfamily and is also known as TNFRSF18 (Shimuzu 2002). As its name implies, GITR expression was first detected in T lymphocytes that had been treated with dexamethasone, a glucocorticoid (Nocentini). In normal naive mice, GITR is expressed at moderate levels on CD25-positive/CD4-positive/CD8a-negative thymocytes and on CD25-positive/CD4-positive/CD45RB-low splenocytes (Shimuzu 2002, Uraushihara). It is also expressed at low levels on splenic CD25-negative/CD4-positive/CD45RB-low T lymphocytes, B lymphocytes, macrophages, and dendritic cells (Shimuzu 2002,Uraushihara). Activation of T and B lymphocytes upregulates GITR expression (Shimuzu 2002). GITR is a costimulatory receptor that plays an important role in Regulatory T (Treg)-cell functions, and a GITR Ligand has been detected on B lymphocytes, macrophages, and dendritic cells (Ji, Tone). mAb DTA-1 abrogates suppression by Treg cells without affecting their proliferative response, while it is co-stimulatory for T lymphocytes that are not Treg cells. (Bielharz, Dittmer, Kohm, Shimizu 2002, Shimizu 2003, Uraushihara).

Host Species: Rat
Clone: DTA-1
Isotype: IgG2b, λ
Cross Reactivity: Mouse

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen GITR
Applications Flow Cytometry
Classification Monoclonal
Clone DTA-1
Concentration 0.2mg/mL
Conjugate PE
Description GITR; Gitr; glucocorticoid-induced TNFR-related protein; Tnfrsf18; AITR
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse CD25+ CD4+ T Cell Line
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b
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For Research Use Only.

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