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GITRL Mouse anti-Human, Clone: 109114, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523852

Catalog No. PIMA523852


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Description

Description

In sandwich ELISAs, no cross-reactivity or interference with recombit human (rh) APRIL, rhLIGHT, rhTNF-alpha, or rhVEGI is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappa-B and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-kappa-B, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Domit negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappa-B activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.
Specifications

Specifications

GITRL
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q9UNG2
RP1-15D23.1, AITRL, GITRL, TL6, hGITRL, AITR ligand, GITR ligand, activation-inducible TNF-related ligand, glucocorticoid-induced TNF-related ligand, glucocorticoid-induced TNFR-related protein ligand, tumor necrosis factor ligand superfamily member 18
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
8995
ELISA, Flow Cytometry, Neutralization
109114
Unconjugated
TNFSF18
Lyophilized
TNFSF18
Sf 21-derived recombit human GITR Ligand/TNFSF18Glu52-Ser177
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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