Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Glucocorticoid Receptor Mouse anti-Human, Unlabeled, Clone: 41, BD
Mouse Monoclonal Antibody
$276.00 - $552.00
Specifications
| Antigen | Glucocorticoid Receptor |
|---|---|
| Clone | 41 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
Description
Steroid hormone receptors are hormone activated transcriptional regulators that influence genes required for embryonic development and adult homeostasis. One member of the steroid hormone family is the glucocorticoid receptor. It contains AF1 and AF2 transactivation domains, a DNA binding domain, and ligand binding domain. Ligand bound glucocorticoid receptors dimerize at specific palindromic sequences called glucocorticoid response elements (GREs) in the cis-regulatory region of target genes. Both AF1 and AF2 may be important for initiation or regulation of transcription by interacting with components of the initiation complex or other intermediary factors. In addition to transactivation, glucocorticoid receptors may also regulate transcription through transrepression of target genes. Although mechanisms of transrepression are not completely understood; DNA binding alone, DNA binding plus interaction with other transcription factors, or protein-protein interaction without DNA binding are mechanisms that have been implicated. Thus, glucocorticoid receptors function in the
regulation of specific genes that are essential for human development and homeostasis.
Host Species: Mouse
Clone: 41
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Glucocorticoid Receptor α aa. 176-289
Formula Weight [Chemical]: 94kDa
Immunofluorescence, Western Blotting
Specifications
| Glucocorticoid Receptor | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 41 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human | |
| Human Glucocorticoid Receptor α aa. 176-289 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
Spot an opportunity for improvement?
Provide Content Correction
Provide Content Correction
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Product Title