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MilliporeSigma™ anti-Glucocorticoid Receptor, Polyclonal

Catalog No. ABE1424MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ABE1424MI 100 μL Unconjugated
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Catalog No. ABE1424MI Supplier MilliporeSigma™ Supplier No. ABE1424
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Description

Rabbit Polyclonal Antibody

Specifically detects Glucocorticoid Receptor Clone: in Human, Mouse samples, and it is validated for Western Blotting

Glucocorticoid receptor (UniProt P04150; also known as GR, Nuclear receptor subfamily 3 group C member 1) is encoded by the NR3C1 (also known as GCCR, GCR, GCRST, GRL) gene (Gene ID 2908) in human. Glucocorticoid receptor is widely expressed in almost all cell types and regulates genes controlling development, metabolism, and immune response upon binding glucocorticoids. Hormone-bound GR translocates from the cytoplasm to the nucleus where it regulates gene transcriptions by binding to glucocorticoid response elements (GREs) or by interacting with various transcription factors. Alternatively, hormone-bound GR can repress gene transcriptions by blocking the nuclear translocation of transcription factors. GR is composed of a modulating domain and a DNA-binding domain at its N-terminal, and a ligand-binding domain at the C-terminal.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Glucocorticoid Receptor
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation Rabbit polyclonal antibody in serum with 0.05% sodium azide.
Gene Accession No. P04150
Gene Symbols NR3C1, GCCR, GCR, GCRST, GRL
Host Species Rabbit
Immunogen KLH-conjugated linear peptide corresponding to a sequence from the modulating region of human glucocorticoid receptor.
Purification Method Unpurified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Epigenetics, Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_000167
Test Specificity Expected to react with all 10 spliced isoforms reported by UniProt (P04150-1 through P04150-10).
Target Species Human, Mouse
Content And Storage −20°C for one year
Form Serum
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For Research Use Only

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