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Description
The H1.1 antibody reacts with gp49B, a structural homolog of the human Killer Inhibitory Receptors (KIR), and with the truncated related molecule gp49A. The gp49 receptors are expressed on myeloid cells of adult bone marrow, spleen, and liver and fetal liver. They are not found on resting lymphoid cells, but their expression is upregulated on activated NK cells. gp49B is a member of the Ig superfamily containing two cytoplasmic ITIM (Immunoreceptor Tyrosine-based Inhibitory Motif) domains, while gp49A has no ITIM. Although its ligand is unknown, it is established that cross-linking of gp49B can suppress cell activation events.
Host Species: Hamster
Clone: H1.1
Isotype: IgG3 κ
Species Reactivity: Mouse
Immunogen: gp49B-Fc fusion protein composed of extracelluar domain of gp49B
ELISA, Flow Cytometry, Immunoprecipitation
Specifications
Specifications
| Antigen | gp49 Receptor |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | H1.1 |
| Concentration | 0.5mg/mL |
| Conjugate | Unconjugated |
| Formulation | Aqueous buffered solution containing ≤0.09% sodium azide. |
| Host Species | Hamster |
| Immunogen | gp49B-Fc fusion protein composed of extracelluar domain of gp49B |
| Purification Method | Affinity Purified |
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For Research Use Only.
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