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Granulysin Mouse anti-Human, Alexa Fluor 488, Clone: RB1, BD

Catalog No. BDB558254 Shop All BD Biosciences Products
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BDB558254 100 Tests
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Catalog No. BDB558254 Supplier BD Biosciences Supplier No. 558254

Description

Mouse Monoclonal Antibody

The monoclonal antibody RB1 recognizes both 15- and 9kDa forms of human granulysin, a protein present in granules of human natural killer (NK) cells and activated cytotoxix T lymphocytes (CTLs). It is cytolytic against both tumor and microbial targets and has been found to kill extracellular and intracellular mycobacterium tuberculosis through a granule-dependent mechanism. Granulysin is a member of a larger family of proteins known as saposin-like proteins (SAPLIP) that are thought to associate with lipids. The crystal structure of granulysin suggests that it functions as a lytic molecule. To date, no granulysin homolog has been found in mice, precluding the generation of granulysin knockout animals.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Granulysin
Applications Flow Cytometry
Classification Monoclonal
Clone RB1
Conjugate Alexa Fluor 488
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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