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Granzyme A Set Mouse anti-Human, FITC, Clone: CB9, BD

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BDB558905 100 Tests
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Catalog No. BDB558905 Supplier BD Biosciences Supplier No. 558905
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Description

Mouse Monoclonal Antibody

The primary mechanism by which cytotoxic T cells eliminate virally infected cells is by granule exocytosis. The release of cytotoxic granule contents by cytotoxic T lymphocytes (CTL) triggers apoptotic target cell death. CTL granules contain a pore-forming protein, perforin, and a group of serine proteases called granzymes. In the classic model, perforins create holes in the target cell membrane, allowing entrance of the granzymes. Granzyme A and B are the predominant granzymes activated after CTL activation, but each act via an independent apoptotic pathway; granzyme B is activated immediately, while granzyme A acts hours later. Granzyme B does not induce cleavage of caspase-3, lamin B, rho-GTPase or PARP, but does cleave DNA-PKcs and nuclear mitotic apparatus protein (NuMA). The physiological substrates for granzyme A in the apoptotic pathway have not been identified. Studies involving mice which are deficient in both granzyme A and B suggest a model whereby the granzyme B pathway may have evolved as the major apoptotic pathway with the granzyme A pathway acting as a backup. However, further research is needed to delineate the components of the distinct pathways.

Clone CB9 recognizes human granzyme A. Purified human granzyme A was used as immunogen. Clone MOPC-21 is a mouse IgG1 isotype (negative) control. The MOPC-21 antibody has unknown specificity. CB9 and MOPC-21 FITC conjugates are optimized in F/P ratios.

The antibodies are routinely tested in parallel by flow cytometry. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Granzyme A Set
Applications Flow Cytometry
Classification Monoclonal
Clone CB9
Conjugate FITC
Host Species Mouse
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Includes FITC Human Granzyme A (100 tests), FITC Mouse IgG1, κ Isotype Control (100 tests)
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1
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