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Granzyme B Mouse anti-Human, PE, Clone: GB11, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 561142
Description
The GB11 antibody specifically reacts with human granzyme B, a serine protease ofapproximately 32 kDa. Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin. In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes. Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis. Granzyme B may also be involved in the hydrolysis of extracellular matrix components. Detectable levels of granzyme B have been detected in sera from healthy volunteers. The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line.

Specifications
Granzyme B | |
Monoclonal | |
PE | |
Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
Human Granzyme B | |
100 Tests | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
Flow Cytometry | |
GB11 | |
GZMB; Granzyme-2; CCPI; CGL1; CSPB; CTLA1; CTSGL1; GRB; HLP; SECT | |
Mouse | |
Affinity Purified | |
RUO | |
Human | |
IgG1 κ |
Safety and Handling
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