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Granzyme B Mouse anti-Human, PE, Clone: GB11, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 561142

Catalog No. BDB561142


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Description

Description

The GB11 antibody specifically reacts with human granzyme B, a serine protease ofapproximately 32 kDa. Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin. In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes. Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis. Granzyme B may also be involved in the hydrolysis of extracellular matrix components. Detectable levels of granzyme B have been detected in sera from healthy volunteers. The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Granzyme B
Monoclonal
PE
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Human Granzyme B
100 Tests
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
GB11
GZMB; Granzyme-2; CCPI; CGL1; CSPB; CTLA1; CTSGL1; GRB; HLP; SECT
Mouse
Affinity Purified
RUO
Human
IgG1 κ
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