GREM1, Mouse, Clone: 2C8, Abnova™

Catalog No.	Quantity
89-123-129	200 μL

Catalog No. 89-123-129 Supplier Abnova Corporation Supplier No. H00026585M02A

Description

Mouse monoclonal antibody raised against a partial recombinant GREM1.

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. [provided by RefSeq

Sequence: ESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD

Specifications

• Antigen: GREM1
• Applications: ELISA
• Classification: Monoclonal
• Clone: 2C8
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant GREM1.
• Formulation: ascites with no preservative
• Gene: GREM1
• Gene Accession No.: NM_013372
• Gene Alias: CKTSF1B1/DAND2/DRM/GREMLIN/IHG-2/MGC126660/PIG2
• Gene Symbols: GREM1
• Host Species: Mouse
• Immunogen: GREM1 (NP_037504, 75 a.a. ∼ 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 26585
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Ascites
• Isotype: IgM κ