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GRIK4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520452

Catalog No. PIPA520452


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Description

Description

Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE. A suggested positive control is rat brain tissue lysate. PA5-20452 can be used with blocking peptide PEP-0569.

Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder.
Specifications

Specifications

Grik4
Polyclonal
Unconjugated
GRIK4
Liquid
GRIK4
A 19 amino acid peptide near the carboxy terminus of the human Grik4.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q16099, Q8BMF5, Q01812
EAA1, GRIK, KA1; excitatory amino acid receptor 1; glutamate receptor KA-1; glutamate receptor KA1; glutamate receptor, ionotropic kainate 4
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
110637, 24406, 2900
Documents
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