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GRIK5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520451

Catalog No. PIPA520451


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-20451 can be used with blocking peptide PEP-0568.

Glutamate receptors are the predomit excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.
Specifications

Specifications

Grik5
Polyclonal
Unconjugated
GRIK5
Liquid
GRIK5
A 17 amino acid peptide near the carboxy terminus of the human Grik5.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q16478, Q61626, Q63273
EAA2, GRIK2, KA2; excitatory amino acid receptor 2; glutamate receptor KA-2; glutamate receptor KA2; glutamate receptor, ionotropic kainate 5
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
14809, 24407, 2901
Documents
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