GS15 Mouse, Unlabeled, Clone: 19, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610961
Eukaryotic protein trafficking involves the packaging of target molecules into membranous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their components into an acceptor compartment. Components of both the vesicle and the synaptic plasma membrane interact to form a fusion complex which mediates specific docking and fusion of vesicles. This complex contains NSF (N-ethyl-maleimide-sensitive factor), SNAPs (soluble NSF attachment proteins), and receptor proteins (SNAREs) that include synaptobrevin, synaptotagmin, syntaxin, and SNAP-25 (synaptosome-associated protein of 25kDa). SNAP-25 and syntaxin are associated with the target plasma membrane (t-SNAREs), while synaptobrevin and synaptotagmin are vesicle-associated proteins (v-SNAREs). In Drosophila, protein transport from the ER to Golgi involves Bet1p, a v-SNARE. With 28% amino acid identity to Bet1p, GS15 (Golgi SNARE of 15kDa) is widely expressed in rat tissues. It is an integral membrane protein of the Golgi apparatus and functions as a SNARE. Thus, GS15 is thought to be a novel SNARE that participates in ER-Golgi protein transport through an undefined process.
Immunofluorescence, Western Blotting
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Golgi SNARE of 15 kDa|
|Rat GS15 aa. 1-85|
|Canine, Frog, Human, Murine, Rat|
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