MilliporeSigma™ anti-GSTA4, Polyclonal

Catalog No.	Quantity	Conjugate
ABS1652MI	100 μL	Unconjugated

Catalog No. ABS1652MI Supplier MilliporeSigma™ Supplier No. ABS1652

Description

Rabbit Polyclonal Antibody

Specifically detects GSTA4 Clone: in Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Glutathione S-transferase alpha-4 (EC:2.5.1.18; UniProt P14942; also known as Glutathione S-transferase A4, Glutathione S-transferase Yk, GST 8-8, GST A4-4, GST K, GST Yk) is encoded by the Gsta4 gene (Gene ID 300850) in rat. Glutathione S-transferases constitute a family of isozymes that are involved in detoxification by catalyzing the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates. The GST family can be subdivided into the cytosolic, mitochondrial, and microsomal (a.k.a. MAPEG) proteins. Mammalian GSTs exist either as homodimers or heterodimers. The individual monomers were historically characterized by their quaternary structure and size, Yf (24.5kDa), Yk (25kDa), Ya1 (25.5kDa), Ya2 (25.5kDa), Yn (26.5kDa), Yb1 (27kDa), Yb2 (27kDa) and Yc (28.5kDa). The Y designation refers to the Y fraction (as opposed to the X and Z fractions) that were found during purification by Sephadex G75 chromatography. Two GST superfamilies exist that comprise either cytosolic or membrane-bound proteins. Evidence suggests that cytosolic GST increases bodily resistance to carcinogens, products of oxidative stress, environmental pollutants and certain anti-cancer drugs. The cytosolic GSTs are further subdivided into eight classes, namely alpha (GSTA), mu (GSTM), pi (GSTP), sigma (GSTS), theta (GSTT), kappa (GSTK), zeta (GSTZ), and omega (GSTO). GSTA4 exists as a homodimer composed of two Yk subunits.

Specifications

• Antigen: GSTA4
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: Rabbit polyclonal antibody in serum with 0.05% sodium azide.
• Gene Accession No.: P14942
• Gene Symbols: Gsta4
• Host Species: Rabbit
• Immunogen: Purified rat liver GST K (YkYk).
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001100310
• Test Specificity: This antiserum selectively reacts with Yk from purified rat liver GST K and rat kidney GST J. No reactivity toward Ya, Yc, Yb1, Yb2, Yb3, Yf, or Yn subunits from other forms of purified rat GSTs (Hayes, J.D,, and Mantle, T.J. (1986). Biochem. J. 233(3):779-788).
• Target Species: Mouse, Rat
• Content And Storage: −20°C for one year
• Form: Serum

For Research Use Only