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Description
The hamster anti-mouse H2-M3 antibody (clone 130) reacts with the H2-M3 major histocompatibility complex (MHC) non-classical class Ib antigen. H2-M3 (M3) associates with β2-microglobulin and is capable of being expressed by most leukocytes. However, due to a lack of endogenous antigens, M3 has been reported to be undetectable on most cells. Its expression is induced by high-affinity N-formylated peptides from mitochondria, Listeria monocytogenes, and Mycobacterium tuberculosis. The induced expression of M3 is most efficient on antigen
presenting cells. M3 presents antigen to cytotoxic T lymphocytes and may play a key role in protective immunity against the intracellular bacteria L. monocytogenes and M. tuberculosis. Furthermore, M3 is capable of presenting mitochondrial antigens for intrathymic positive selection of T-cell receptors which recognize those peptides.
Host Species: Hamster
Clone: 130
Isotype: IgG1 κ
Species Reactivity: Mouse
Immunogen: Purified soluble complex of recombinant truncated M3 and β2-microglobulin
Flow Cytometry, Immunoprecipitation
Specifications
Specifications
| Antigen | H2-M3 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | 130 |
| Concentration | 0.5mg/mL |
| Conjugate | Unconjugated |
| Formulation | Aqueous buffered solution containing ≤0.09% sodium azide. |
| Host Species | Hamster |
| Immunogen | Purified soluble complex of recombinant truncated M3 and β2-microglobulin |
| Purification Method | Affinity Purified |
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For Research Use Only.
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