H2-M3 Hamster anti-Mouse, Unlabeled, Clone: 130, BD

Hamster Monoclonal Antibody

Supplier:  BD Biosciences 551769

Catalog No. BDB551769

Description

The hamster anti-mouse H2-M3 antibody (clone 130) reacts with the H2-M3 major histocompatibility complex (MHC) non-classical class Ib antigen. H2-M3 (M3) associates with β2-microglobulin and is capable of being expressed by most leukocytes. However, due to a lack of endogenous antigens, M3 has been reported to be undetectable on most cells. Its expression is induced by high-affinity N-formylated peptides from mitochondria, Listeria monocytogenes, and Mycobacterium tuberculosis. The induced expression of M3 is most efficient on antigen
presenting cells. M3 presents antigen to cytotoxic T lymphocytes and may play a key role in protective immunity against the intracellular bacteria L. monocytogenes and M. tuberculosis. Furthermore, M3 is capable of presenting mitochondrial antigens for intrathymic positive selection of T-cell receptors which recognize those peptides.

Host Species: Hamster
Clone: 130
Isotype: IgG1 κ
Species Reactivity: Mouse
Immunogen: Purified soluble complex of recombinant truncated M3 and β2-microglobulin

Flow Cytometry, Immunoprecipitation

Specifications

• Antigen: H2-M3
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Purified soluble complex of recombinant truncated M3 and β2-microglobulin
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Mouse
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: 130
• Conjugate: Unconjugated
• Host Species: Hamster
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.