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H2-M3 Hamster anti-Mouse, Unlabeled, Clone: 130, BD

Catalog No. BDB551769 Shop All BD Biosciences Products
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Catalog No. BDB551769 Supplier BD Biosciences Supplier No. 551769

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Hamster Monoclonal Antibody

The hamster anti-mouse H2-M3 antibody (clone 130) reacts with the H2-M3 major histocompatibility complex (MHC) non-classical class Ib antigen. H2-M3 (M3) associates with β2-microglobulin and is capable of being expressed by most leukocytes. However, due to a lack of endogenous antigens, M3 has been reported to be undetectable on most cells. Its expression is induced by high-affinity N-formylated peptides from mitochondria, Listeria monocytogenes, and Mycobacterium tuberculosis. The induced expression of M3 is most efficient on antigen
presenting cells. M3 presents antigen to cytotoxic T lymphocytes and may play a key role in protective immunity against the intracellular bacteria L. monocytogenes and M. tuberculosis. Furthermore, M3 is capable of presenting mitochondrial antigens for intrathymic positive selection of T-cell receptors which recognize those peptides.

Host Species: Hamster
Clone: 130
Isotype: IgG1 κ
Species Reactivity: Mouse
Immunogen: Purified soluble complex of recombinant truncated M3 and β2-microglobulin

Flow Cytometry, Immunoprecipitation

TRUSTED_SUSTAINABILITY

Specifications

Antigen H2-M3
Applications Flow Cytometry
Classification Monoclonal
Clone 130
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Hamster
Immunogen Purified soluble complex of recombinant truncated M3 and β2-microglobulin
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG1
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For Research Use Only.

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