HEC Mouse, Unlabeled, Clone: 1, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611040
Cell division is a highly regulated process which ensures that properly replicated DNA is received by both daughter cells. During M phase, the pairs of sister chromatids separate into each daughter cell. To ensure correct cell division, each step of this process is highly regulated by proteins such as kinases and phosphatases that serve as checkpoints. HEC (highly expressed in cancer) was discovered during a search for mitotic proteins that might provide insight to the progression of malignant cells. HEC was identified via its interaction with Rb (retinoblastoma protein) in the yeast two hybrid system. Its expression is elevated during M phase, and it localizes to the centromeres during this time of rapid division. During G1 HEC is dispersed in the nucleus. In addition, HEC is abundant in rapidly dividing cancer cells, but is absent from terminally differentiated cells. Also, microinjection of HEC antibodies resulted in abnormal chromosome distribution. Therefore, HEC is thought to play a role in chromosome segregation during the M phase of the cell cycle.
Immunofluorescence, Western Blotting
|Immunofluorescence, Western Blot|
|Human HEC aa. 495-608|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
For Research Use Only.