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HEC Mouse, Unlabeled, Clone: 1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611040

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Catalog No. BDB611040

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Cell division is a highly regulated process which ensures that properly replicated DNA is received by both daughter cells. During M phase, the pairs of sister chromatids separate into each daughter cell. To ensure correct cell division, each step of this process is highly regulated by proteins such as kinases and phosphatases that serve as checkpoints. HEC (highly expressed in cancer) was discovered during a search for mitotic proteins that might provide insight to the progression of malignant cells. HEC was identified via its interaction with Rb (retinoblastoma protein) in the yeast two hybrid system. Its expression is elevated during M phase, and it localizes to the centromeres during this time of rapid division. During G1 HEC is dispersed in the nucleus. In addition, HEC is abundant in rapidly dividing cancer cells, but is absent from terminally differentiated cells. Also, microinjection of HEC antibodies resulted in abnormal chromosome distribution. Therefore, HEC is thought to play a role in chromosome segregation during the M phase of the cell cycle.

Immunofluorescence, Western Blotting

Specifications

Specifications

HEC
1
Unconjugated
Murine
IgG1
RUO
Primary
Canine, Human
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human HEC aa. 495-608
50μg
Cell Biology
Monoclonal
Documents
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