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HEC Mouse, Unlabeled, Clone: 1, BD

Catalog No. BDB611040 Shop All BD Biosciences Products
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BDB611040 50 μg
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Catalog No. BDB611040 Supplier BD Biosciences Supplier No. 611040

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Mouse Monoclonal Antibody

Cell division is a highly regulated process which ensures that properly replicated DNA is received by both daughter cells. During M phase, the pairs of sister chromatids separate into each daughter cell. To ensure correct cell division, each step of this process is highly regulated by proteins such as kinases and phosphatases that serve as checkpoints. HEC (highly expressed in cancer) was discovered during a search for mitotic proteins that might provide insight to the progression of malignant cells. HEC was identified via its interaction with Rb (retinoblastoma protein) in the yeast two hybrid system. Its expression is elevated during M phase, and it localizes to the centromeres during this time of rapid division. During G1 HEC is dispersed in the nucleus. In addition, HEC is abundant in rapidly dividing cancer cells, but is absent from terminally differentiated cells. Also, microinjection of HEC antibodies resulted in abnormal chromosome distribution. Therefore, HEC is thought to play a role in chromosome segregation during the M phase of the cell cycle.

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen HEC
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 1
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Human HEC aa. 495-608
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Human
Isotype IgG1
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For Research Use Only.

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