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  6. Heme Oxygenase 1 Mouse anti-Human, Unlabeled, Clone: 23, BD

Heme Oxygenase 1 Mouse anti-Human, Unlabeled, Clone: 23, BD

Catalog No. BDB610713 Shop All BD Biosciences Products
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BDB610713 150 μg
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Catalog No. BDB610713 Supplier BD Biosciences Supplier No. 610713
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Description

Mouse Monoclonal Antibody

Heme oxygenases 1 and 2 (HO-1, HO-2) cleave the heme molecule, resulting in the production of carbon monoxide (CO) and biliverdin. HO-1 is a 288 amino acid monooxygenase with a molecular weight of 32kDa. While HO-2 is constitutively expressed in tissues, HO-1 is rapidly induced by several stimuli such as lutathione depletion, hemin, heat shock, heavy metals, oxidative stress, oxidized LDL, anoxia, and endotoxic shock. Similar to nitric oxide (NO), CO activates guanylate cyclase and reduces platelet aggregation. Several conditions that increase NO also induce HO-1 expression and activity. This suggests that NO synthases, Cox-2, and HO-1 are part of a general defense mechanism against stress and pathogen invasion.

Immunofluorescence, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Heme Oxygenase 1
Applications Western Blot
Classification Monoclonal
Clone 23
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Heme Oxygenase 1 (HO-1) aa. 150-286
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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