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TIM-1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141210

Catalog No. 01-675-770


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Description

Description

HAVCR1, a 359 A.A Class 1 integral membrane glycoprotein, is used by Hepatitis A virus to infect humans. It consists of a conserved N-terminal Cys-rich region, IgV (Immunoglobulin Variable region like) domain and a TSP-rich mucin domain in the extracellular region followed by a highly conserved tyrosine kinase phosphorylation motif in the cytoplasmic region. HAVCR1 is expressed on terminally differentiated CD4+ Th2 cells and regulates cytokine production. It plays an important role in the regulation of immune responses in the development of asthma and allergic responses. Its expression is critically upregulated in dedifferentiated kidney cells, thus indicating a possible role in regeneration of proximal tubule epithelium in Kidneys. HAVCR1 has shown to be upregulated in renal carcinomas, suggesting its role in tumor progression and metastasis.

Suggested positive control: human and mouse brain tissue lysate or protein.
Specifications

Specifications

TIM-1
Polyclonal
Unconjugated
PBS with 0.05% BSA and 0.05% sodium azide
Q96D42, Q5QNS5
HAVCR1, TIM-1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
171283, 26762
Western Blot
0.5 mg/mL
1-3ug/mL
HAVCR1
Liquid
HAVCR1
Synthetic peptide corresponding to residues 200-300 of human HaVCR1 protein.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse
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