homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1, Mouse, Clone: 3E10, Abnova™

Catalog No.	Quantity
89-001-149	100 μg

Catalog No. 89-001-149 Supplier Abnova Corporation Supplier No. H00009709M01

Description

Mouse monoclonal antibody raised against a full-length recombinant HERPUD1.

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq

Sequence: MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN

Specifications

• Antigen: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 3E10
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a full length recombinant HERPUD1.
• Formulation: PBS with no preservative; pH 7.4
• Gene: HERPUD1
• Gene Accession No.: BC000086
• Gene Alias: HERP/KIAA0025/Mif1/SUP
• Gene Symbols: HERPUD1
• Host Species: Mouse
• Immunogen: HERPUD1 (AAH00086, 1 a.a. ∼ 391 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Whole Molecule: Yes
• Primary or Secondary: Primary
• Gene ID (Entrez): 9709
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Isotype: IgG1 κ