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HIF1A Rabbit anti-Goat, Hamster, Human, Mouse, Non-human primate, Rabbit, Rat, DyLight® 550, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522780

Catalog No. PIPA522780


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Description

Description

This antibody detects upregulation of HIF-1 alpha in hypoxic samples.

HIF1-alpha (HIF1A) is a subunit of HIF1, which is a transcription factor found in mammalian cells cultured under reduced oxygen tension. HIF-1 is a heterodimer consisting of an alpha and beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors. HIF1 functions as a transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, HIF-1 activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF1-alpha regulates hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis. Hypoxia which induces p53 protein accumulation, directly interacts with HIF1-alpha and reduces hypoxia-induced expression of HIF1-alpha by promoting MDM2-mediated ubiquitination and proteasomal degradation under hypoxic conditions. Recent studies suggest that induction of NOX4 by HIF1-alpha contributes to maintain ROS levels after hypoxia and hypoxia-induced proliferation. In humans, it is located on the q arm of chromosome 14. The C-terminal of HIF1A binds to p300. p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including VEGF. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease.
Specifications

Specifications

HIF1A
Polyclonal
DyLight® 550
HIF1A
Liquid
HIF1A
A fusion protein including residues 530-825 of the mouse HIF-1 alpha protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Goat, Hamster, Human, Mouse, Non-human primate, Rabbit, Rat
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
0.82 mg/mL
50mM sodium borate with 0.05% sodium azide
Q16665, Q61221, O35800
HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, ARNT interacting protein, ARNT-interacting protein, HIF-1-alpha, PAS domain-containing protein 8, basic-helix-loop-helix-PAS protein MOP1, class E basic helix-loop-helix protein 78, hypoxia-inducible factor 1 alpha isoform I.3, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1-alpha, member of PAS protein 1, member of PAS superfamily 1
Rabbit
IgG
100 μL
4° C, store in dark
Primary
100009579, 100751293, 100861391, 15251, 29560, 3091
Documents
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