MilliporeSigma™ anti-Histone H2B type 2-E (H2be), Polyclonal

Catalog No.	Quantity	Conjugate
ABE1384MI	50 μg	Unconjugated

Catalog No. ABE1384MI Supplier MilliporeSigma™ Supplier No. ABE1384

Description

Rabbit Polyclonal Antibody

Specifically detects Histone H2B type 2-E (H2be) Clone: in Human, Mouse, Rat samples, and it is validated for Dot Blot, Western Blotting

Histone H2B type 2-E (UniProt Q64524; also known as H2b 613, Histone 2 H2be) is encoded by the Hist2h2be gene (Gene ID 319190) in murine species. H2be is a replication-independent histone H2b variant expressed exclusively in olfactory chemosensory neurons. Levels of H2be are heterogeneous among olfactory neurons, but stereotyped according to the identity of the co-expressed olfactory receptor (OR). H2be is nearly undetectable in highly active neurons, but almost completely replaces H2b in inactive neurons. Changes in H2be expression affect olfactory function and OR representation in the adult olfactory epithelium. Genetic studies show that the deletion of H2be significantly extends the lifespan of neurons, whereas elevated H2be shortens their lifespan.

Specifications

• Antigen: Histone H2B type 2-E (H2be)
• Applications: Dot Blot, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: Q64524
• Gene Symbols: Hist2h2be
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to the N-terminal sequence of mouse histone H2B type 2-E (H2be).
• Purification Method: Affinity Purified
• Quantity: 50 μg
• Regulatory Status: RUO
• Research Discipline: Epigenetics, Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_835586
• Test Specificity: The identity of an immunoreactive band of ∽16kDa detected by this polyclonal antibody using HeLa cell lysate has not been determined, but most likely corresponds to human histone H2B type 1-L (Histone H2B.c; Uniprot Q99880) whose N-terminal sequence (up to a.a. 39) is identical to that of murine histone H2B type 2-E.
• Target Species: Human, Mouse, Rat
• Content And Storage: 2°C to 8°C for one year

For Research Use Only