HLA-A2 Mouse anti-Human, Unlabeled, Clone: BB7.2, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 551230

Catalog No. BDB551230

Description

The monoclonal antibody BB7.2 reacts with a subunit of the human leukocyte antigen-A2 (HLA-A2), a class I molecule of the major histocompatibility complex (MHC). The MHC gene locus encodes a group of highly polymorphic, cell-surface proteins that play a broad role in the immune response to protein antigens. MHC molecules function by binding and presenting small antigenic protein fragments to antigen-specific receptors expressed by T cells (TCR). Human (human leukocyte antigen/HLA) MHC molecules comprise two major classes, MHC class I and class II. Functionally, class I MHC molecules can bind peptides derived from intracellular antigens (eg, viral and some bacterial antigens) that are specifically recognized by CD8+ T cells, and class II MHC molecules recognize antigens derived from pathogens multiplying in intracellular vesicles, and those derived from ingested extracellular bacteria. When presented on the cell surface by the MHC class II molecules, these antigens are recognized by CD4+ T cells. TCR recognize both processed peptides bound to MHC, as well as regions of the MHC molecule itself. CD4 and CD8 accessory molecules strengthen formation of the TCR-MHC complex through their interaction with non-polymorphic regions of the MHC molecule.

Host Species: Mouse
Clone: BB7.2
Isotype: IgG2b κ
Species Reactivity: Human

Flow Cytometry

Specifications

• Antigen: HLA-A2
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: BB7.2
• Conjugate: Unconjugated
• Host Species: Mouse
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG2b κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.