HLA-DRA Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527553
PA5-27553 targets HLA-DRA in WB and IHC (P) applications and shows reactivity with Human samples. The PA5-27553 immunogen is recombit fragment corresponding to a region within amino acids 1 and 141 of Human HLA-DRA. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
|Recombit fragment corresponding to a region within amino acids 1 and 141 of Human HLA-DRA|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 10% glycerol and 0.01% thimerosal; pH 7|
|HLA-DRA1, MLRW, HLA class II histocompatibility antigen, DR alpha chain, MHC cell surface glycoprotein, MHC class II antigen DRA, histocompatibility antigen HLA-DR alpha|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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