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HLA-DRA Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527553

Catalog No. PIPA527553


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Description

Description

PA5-27553 targets HLA-DRA in WB and IHC (P) applications and shows reactivity with Human samples. The PA5-27553 immunogen is recombit fragment corresponding to a region within amino acids 1 and 141 of Human HLA-DRA. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Specifications

Specifications

HLA-DRA
Polyclonal
Unconjugated
HLA-DRA
Liquid
HLA-DRA
Recombit fragment corresponding to a region within amino acids 1 and 141 of Human HLA-DRA
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
0.21 mg/mL
PBS with 10% glycerol and 0.01% thimerosal; pH 7
P01903
HLA-DRA1, MLRW, HLA class II histocompatibility antigen, DR alpha chain, MHC cell surface glycoprotein, MHC class II antigen DRA, histocompatibility antigen HLA-DR alpha
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
3122
Documents
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