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HLA-DRB5 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525234

Catalog No. PIPA525234

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Specifications

Specifications

HLA-DRB5
Polyclonal
PBS with 0.09% sodium azide
Q30154
HLA-DRB, DR beta-5, DR-9, DR2-beta-2, DR9, HLA class II histocompatibility antigen, DR beta 5 chain, HLA class II histocompatibility antigen, DR-5 beta chain, HLA class II histocompatibility antigen, DRB1-9 beta chain, MHC HLA-DR-beta cell surface glycoprotein, MHC HLA-DR
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3127
Immunohistochemistry, Western Blot
Unconjugated
HLA-DRB5
Liquid
HLA-DRB5
KLH conjugated synthetic peptide between 43-70 amino acids from the central region of human HLA-DRB5
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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