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MilliporeSigma™ anti-HLCS Clone: 2C2.1,

Catalog No. MABE968MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABE968MI 100 μg Unconjugated
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Catalog No. MABE968MI Supplier MilliporeSigma™ Supplier No. MABE968
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Description

Mouse Monoclonal Antibody

Specifically detects HLCS Clone: 2C2.1 in Human samples, and it is validated for Western Blotting

Biotin-protein ligase (EC 6.3.4.9; EC 6.3.4.10; EC 6.3.4.11; EC 6.3.4.15; UniProt P50747; also known as Biotin-[acetyl-CoA-carboxylase] ligase, Biotin apo-protein ligase, Biotin-[methylcrotonoyl-CoA-carboxylase] ligase, Biotin-[methylmalonyl-CoA-carboxytransferase] ligase, Biotin-[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase, HCS, Holocarboxylase synthetase) is encoded by the HLCS (also known as HCS) gene (Gene ID 3141) in human. HLCS (holocarboxylase synthetase) is the sole biotin protein ligase encoded by the human genome. HLCS catalyses the covalent modification of target lysine residues by biotin. In addiition to taregting various carboxylases in the cytoplasm and mitochondria, both the full-length HLCS and a splicing variant are reported to enter the nucleus and associate with multi-protein gene repression complex. HLCS overexpression in HEK293 cells is reported to downregulate histone H3 lysine9 acetylation (H3K9ac) level with a cocomitant drop in LTRs (long terminal repeats) 15 and 22 due to a decrease in mRNA coding for LTRs. HLCS is also reported to induce RANTES expression in HEK-293 cells by biotinylating heat shock protein 72 (HSP72).
TRUSTED_SUSTAINABILITY

Specifications

Antigen HLCS
Applications Western Blot
Classification Monoclonal
Clone 2C2.1
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P50747
Gene Symbols HLCS
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to the N-terminal region of human HLCS.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NP_000402
Target Species Human
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG2a κ
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For Research Use Only

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