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HNF-1α Mouse, Unlabeled, Clone: 2, BD

Catalog No. BDB610903 Shop All BD Biosciences Products
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BDB610903 150 μg
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Catalog No. BDB610903 Supplier BD Biosciences Supplier No. 610903

Description

Mouse Monoclonal Antibody

HNF-1 (Hepatocyte Nuclear Factor 1), a POU-homeodomain containing transcription factor, is a family member of liver-enriched transcription factors that also includes C-EBP, HNF-3, and HNF-4. Although HNF-1 exhibits elevated expression in liver and is thought to be involved in liver organogenesis, it is also found in kidney, stomach, intestine, and at a low level in thymus and spleen. A short N-terminal α-helical segment allows for HNF-1 homodimerization which is followed by DNA binding via an atypical helix-turn-helix motif. The HNF-1 dimer transactivates hepatic genes such as α- and β-fibrinogen, α-fetoprotein, albumin, α-L-antitrypsin, and pyruvate kinase by binding to a
highly conserved 13 bp inverted palindromic sequence, GTTAATNATTAAC. HNF-1 represses its own transcription and data suggests that there is coordinate regulation between HNF-1 and HNF-4. Although HNF-4 induces HNF-1 transcription, HNF-1 downregulates HNF-4 activity by binding to the AF2 region in the activation domain of HNF-4. The ability of HNF-1 to dictate the production or activity of itself and other transcription factors indicates its possible function as a general cellular control mechanism.

TRUSTED_SUSTAINABILITY

Specifications

Antigen HNF-1α
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 2
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Mouse HNF-1 aa. 70-269
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rabbit, Rat
Isotype IgG1
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