HNF-1α Mouse, Unlabeled, Clone: 2, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610903
HNF-1 (Hepatocyte Nuclear Factor 1), a POU-homeodomain containing transcription factor, is a family member of liver-enriched transcription factors that also includes C-EBP, HNF-3, and HNF-4. Although HNF-1 exhibits elevated expression in liver and is thought to be involved in liver organogenesis, it is also found in kidney, stomach, intestine, and at a low level in thymus and spleen. A short N-terminal α-helical segment allows for HNF-1 homodimerization which is followed by DNA binding via an atypical helix-turn-helix motif. The HNF-1 dimer transactivates hepatic genes such as α- and β-fibrinogen, α-fetoprotein, albumin, α-L-antitrypsin, and pyruvate kinase by binding to a
highly conserved 13 bp inverted palindromic sequence, GTTAATNATTAAC. HNF-1 represses its own transcription and data suggests that there is coordinate regulation between HNF-1 and HNF-4. Although HNF-4 induces HNF-1 transcription, HNF-1 downregulates HNF-4 activity by binding to the AF2 region in the activation domain of HNF-4. The ability of HNF-1 to dictate the production or activity of itself and other transcription factors indicates its possible function as a general cellular control mechanism.
|Human, Murine, Rabbit, Rat|
|Immunofluorescence, Western Blot|
|Mouse HNF-1 aa. 70-269|
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