Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

HNF-1α Mouse, Unlabeled, Clone: 2, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610903

Catalog No. BDB610903

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.



HNF-1 (Hepatocyte Nuclear Factor 1), a POU-homeodomain containing transcription factor, is a family member of liver-enriched transcription factors that also includes C-EBP, HNF-3, and HNF-4. Although HNF-1 exhibits elevated expression in liver and is thought to be involved in liver organogenesis, it is also found in kidney, stomach, intestine, and at a low level in thymus and spleen. A short N-terminal α-helical segment allows for HNF-1 homodimerization which is followed by DNA binding via an atypical helix-turn-helix motif. The HNF-1 dimer transactivates hepatic genes such as α- and β-fibrinogen, α-fetoprotein, albumin, α-L-antitrypsin, and pyruvate kinase by binding to a
highly conserved 13 bp inverted palindromic sequence, GTTAATNATTAAC. HNF-1 represses its own transcription and data suggests that there is coordinate regulation between HNF-1 and HNF-4. Although HNF-4 induces HNF-1 transcription, HNF-1 downregulates HNF-4 activity by binding to the AF2 region in the activation domain of HNF-4. The ability of HNF-1 to dictate the production or activity of itself and other transcription factors indicates its possible function as a general cellular control mechanism.



Human, Murine, Rabbit, Rat
Immunofluorescence, Western Blot
Affinity Purified
Mouse HNF-1 aa. 70-269
Cell Biology
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit