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HNF-1β Mouse, Unlabeled, Clone: 25, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612504

Catalog No. BDB612504


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Description

Description

HNF's (Hepatocyte Nuclear Factor) are POU-homeodomain-containing liver enriched transcription factors that include HNF1-α, HNF1-β, HNF-3α, HNF-3β, HNF-4 and HNF-6. HNF-1 is expressed in liver, kidney, and intestine, while HNF-1β is expressed highest in kidney with lower levels in intestine, lung, and liver. Both HNF-1 and HNF-1β have short N-terminal α-helical segments that facilitate homodimerization (A-domain), a region related to POU-specific A-box (B-domain), and a homeodomain (C-domain). The HNF-1 and HNF-1β homo- and hetero-dimers transactivate genes required for development of various tissues. Both transcription factors can bind the consensus HNF1 inverted palindromic sequence GTTAATNATTAAC. HNF-1 represses its own transcription and data suggests that there is coordinate regulation between HNF-1 and HNF-4. Although HNF-4 induces HNF-1 transcription, HNF-1 downregulates HNF-4 activity by binding to the AF2 region in the activation domain of HNF-4. Thus, HNF transcription factors may be involved in various aspects of the regulation of gene transcription throughout development.

Immunofluorescence, Western Blotting

Specifications

Specifications

HNF-1β
25
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Hepatocyte Nuclear Factor-1β
Affinity Purified
Mouse HNF-1β aa. 1-101
50μg
Cell Biology
Primary
Canine, Human, Murine, Rat
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