HNF-1β Mouse, Unlabeled, Clone: 25, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612504
HNF's (Hepatocyte Nuclear Factor) are POU-homeodomain-containing liver enriched transcription factors that include HNF1-α, HNF1-β, HNF-3α, HNF-3β, HNF-4 and HNF-6. HNF-1 is expressed in liver, kidney, and intestine, while HNF-1β is expressed highest in kidney with lower levels in intestine, lung, and liver. Both HNF-1 and HNF-1β have short N-terminal α-helical segments that facilitate homodimerization (A-domain), a region related to POU-specific A-box (B-domain), and a homeodomain (C-domain). The HNF-1 and HNF-1β homo- and hetero-dimers transactivate genes required for development of various tissues. Both transcription factors can bind the consensus HNF1 inverted palindromic sequence GTTAATNATTAAC. HNF-1 represses its own transcription and data suggests that there is coordinate regulation between HNF-1 and HNF-4. Although HNF-4 induces HNF-1 transcription, HNF-1 downregulates HNF-4 activity by binding to the AF2 region in the activation domain of HNF-4. Thus, HNF transcription factors may be involved in various aspects of the regulation of gene transcription throughout development.
Immunofluorescence, Western Blotting
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Hepatocyte Nuclear Factor-1β|
|Mouse HNF-1β aa. 1-101|
|Canine, Human, Murine, Rat|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok