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HRD1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA146121

Catalog No. PA146121


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Description

Description

Suggested positive control: 293T, INS-1, and MIN6 cell lysates, antigen standard for SYVN1 (transient overexpression lysate).

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.
Specifications

Specifications

HRD1
Polyclonal
whole serum with no preservative
Q86TM6, Q9DBY1
HRD1, KIAA1810, MGC40372
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
SYVN1
Liquid
SYVN1
A synthetic peptide made to an internal portion of the human protein (within residues 300-400). [UniProt Q96PK3]
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
74126, 84447
Documents
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