HRD1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA146121
Suggested positive control: 293T, INS-1, and MIN6 cell lysates, antigen standard for SYVN1 (transient overexpression lysate).HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.
|whole serum with no preservative|
|HRD1, KIAA1810, MGC40372|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|A synthetic peptide made to an internal portion of the human protein (within residues 300-400). [UniProt Q96PK3]|
|-20° C, Avoid Freeze/Thaw Cycles|
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