Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ anti-Hsp72/73 Clone: W27,

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ HSP01100UG

Catalog No. HSP01100UG

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Specifically detects Hsp72/73 Clone: W27 in Human, Mouse, Rat samples, and it is validated for Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation

The heat shock response was first described for Drosophila salivary gland cells, and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial, chicken, and mammalian cells, and were subsequently studied in most organisms. A series of heatshock proteins Hsp 90, Hsp 70, Hsp 20-30 and ubiquitin (8,000 m.w.) are induced by insults such as temperature shock, chemicals and other environmental stress. Hsp 70 levels increase 1000-fold in mammalian and Drosophila cells following induction. This protein concentrates in nuclei during heat shock and returns to the cytoplasm when the shock is removed. The exact function(s) of the Hsp 70 and other heat shock proteins are not known. Mammalian Hsp 72/73 is reported to be structurally and functionally related to a protein that releases clathrin triskelia from coated vesicles; Hsp 72/73 is known to bind ATP without hydrolyzing it.
Specifications

Specifications

Hsp72/73
W27
In 0.05M sodium phosphate buffer, 0.2% gelatin.
Murine
IgG2a
RUO
Primary
Recognizes the ∽72kDa constitutive and inducible forms of Hsp72/73 in heat-shocked HeLa cells.
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
Purified
purified Hsp72/73
100μg
2°C to 8°C
Monoclonal
Human, Murine, Rat
SDS
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only