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in Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141610

Catalog No. 01-675-227


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Description

Description

Humanin is a novel 24 A.A polypeptide identified in Alzheimer’s disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer’s disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.

Suggested positive control: recombinant fusion protein.
Specifications

Specifications

Humanin
Polyclonal
whole serum with 50% glycerol and 0.025% sodium azide
Q8IVG9
BCL2L4
Rabbit
IgG
RUO
Antibody
Polyclonal
Human
ELISA, Western Blot
Unconjugated
MT-RNR2
Liquid
MT-RNR2
Synthetic peptide corresponding to residues 12-24 of human humanin.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4550
Documents
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