Invitrogen™ Humanin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA14358

Catalog No. PA14358

Description

PA1-4358 detects Humanin from human samples. PA1-4358 has been successfully used in Western blot procedures. The PA1-4358 immunogen is a synthetic peptide corresponding to residues L(9) L L L T S E I D L P V K R R A(24) of human Humanin.

Humanin is a novel 24 A. A polypeptide identified in Alzheimer's disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.

Specifications

• Antigen: Humanin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MT-RNR2
• Gene Alias: BCL2L4; HN1; Humanin-like 1; humanin-like protein 1; mitochondrially encoded 16S RNA; MTRNR2; MT-RNR2; MTRNR2L1; MT-RNR2-like 1; MTRNR2-like 1; MT-RNR2-like protein 1; RNR2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4550
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8IVG9
• Gene Symbols: MT-RNR2
• Immunogen: Synthetic peptide corresponding to residues L(9) L L L T S E I D L P V K R R A(24) of human Humanin.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG