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Description
The 10-3.6 antibody reacts with the β chain of the I-A[k] MHC class II alloantigen. It cross-reacts with splenocytes from mice of the H-2[f], H-2[r], and H-2[s] haplotypes, from nonobese diabetic (NOD, H-2[g7]) mice, and with lymph node cells of BN, DA, WRA, and WRC rats. Reactivity with other haplotypes (e.g., b, d, p, q) has not been observed. Long-term in vivo treatment with 10-3.6 mAb has been reported to prevent the spontaneous development of autoimmune insulin-dependent diabetes mellitus (IDDM) in female NOD mice.
Specifications
Specifications
| Antigen | I-Ak |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | 10-3.6 |
| Concentration | 0.5mg/mL |
| Conjugate | FITC |
| Description | Aβk |
| Formulation | Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide. |
| Host Species | Mouse |
| Immunogen | C3H mouse splenocytes |
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