MilliporeSigma™ anti-Iba1/AIF1 Alexa Fluor 555, Clone: 20A12.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABN92AF555

Catalog No. MABN92AF555

Description

Specifically detects Iba1/AIF1 Clone: 20A12.1 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry

Allograft inflammatory factor 1 (UniProt P55008; also known as AIF-1, Daintain, Interferon gamma responsive transcript, Ionized calcium-binding adapter molecule 1, Protein G1) is encoded by the AIF1 (also known as G1, IBA1) gene (Gene ID 199) in human. Iba1/AIF1 is a 17kDa interferon-gamma- (IFN-gamma-) inducible, Ca(2+)-binding EF-hand protein. Iba1/AIF1 expression is mostly limited to the macrophage/monocyte lineage, and is augmented by cytokines, such as IFN-gamma. It is reported to be involved in neuronal function, inflammatory responses, allograft rejection, autoimmunity, and macrophage activation/function. It is also shown to be expressed in microglial cells in autominnume disesase models such as experimental autoimmune encephalomyelitis, neuritis and uveitis.

Specifications

• Antigen: Iba1/AIF1
• Classification: Monoclonal
• Conjugate: Alexa Fluor 555
• Gene Accession No.: P55008
• Host Species: Mouse
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Purified

• Applications: Immunohistochemistry
• Clone: 20A12.1
• Formulation: Purified mouse antibody conjugate in PBS with 15mg/mL BSA and 0.1 % sodium azide.
• Gene Symbols: AIF1, G1, IBA1
• Immunogen: Linear peptide corresponding to a human Iba1/AIF1 sequence.
• Quantity: 100 μL
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_001614
• Content And Storage: 2°C to 8°C for one year from date of shipment
• Isotype: IgG1 κ

For Research Use Only