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MilliporeSigma™ anti-IDO-1 Clone: 4B7,

Catalog No. MABF850MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABF850MI 100 μg Unconjugated
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Catalog No. MABF850MI Supplier MilliporeSigma™ Supplier No. MABF850
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Description

Mouse Monoclonal Antibody

Specifically detects IDO-1 Clone: 4B7 in Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Indoleamine 2,3-dioxygenase 1 (EC 1.13.11.52; UniProt P28776; also known as IDO-1, indole 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase) is encoded by the Ido1 (also known as Ido, Indo) gene (Gene ID 15930) in murine species. Indoleamine 2,3-dioxygenase-1 (IDO1) is a heme containing enzyme that catalyzes the rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. The reduction in local tryptophan and the upregulated immunomodulatory tryptophan metabolites form the basis of IDO-dependent regulation of inflammation and immunity. IDO is reported to support carcinogenesis by modulating tissue microenvironment inflammatory responses. IDO is also reported to mediate immune escape in cancer by suppressing the function of T effector cells and promote the differentiation of T regulatory cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IDO-1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 4B7
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P28776
Gene Symbols Ido1, Ido, Indo
Host Species Mouse
Immunogen KLH-conjugated linear peptide corresponding to the N-terminal region of mouse IDO-1.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation, Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_032350
Test Specificity Target specificity of clone 4B7 has been confirmed by both immunohistochemistry and Western blotting using tissue samples from wild-type and Ido1-knockout mice (Thomas, S., et al. (2014). J. Cell. Biochem. 115(2):391-396).
Target Species Mouse, Rat
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG1 κ
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For Research Use Only

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