IFN-a/b Receptor 1 Mouse anti-Mouse, NA/LE, Unlabeled, Clone: MAR1-5A3, BD

Catalog No.	Quantity
BDB561183	0.5 mg

Catalog No. BDB561183 Supplier BD Biosciences Supplier No. 561183

Description

Mouse Monoclonal Antibody

The MAR1-5A3 monoclonal antibody specifically binds to the IFN-α/β Receptor 1 (also known as Interferon-alpha/beta Receptor 1; Type I Interferon Receptor 1 or IFNAR-1) subunit. A variety of cell types including lymphocytes, monocytes/macrophages, dendritic cells, and fibroblasts can be stimulated or induced by viral and microbial infections to produce and secrete type I interferons, including Interferon-alpha (IFN-α) subtypes and Interferon-beta (IFN- β). IFN-α subtypes and IFN-β bind to a common heterodimeric receptor complex (also known as the Type I IFN Receptor or IFN-α/β Receptor) that is comprised of transmembrane glycoprotein IFNAR-1 and IFNR-2 subunits and is expressed on most cell types. Upon ligand binding, IFNAR-1 and IFNAR-2 signal cellular responses. Type I interferons are multifunctional proteins that can induce antiviral states in cells as well as regulate the activation, growth, proliferation, differentiation and viability of various cell types including cells that mediate innate and adaptive immunity as well as autoimmune diseases. The MAR1-5A3 monoclonal antibody blocks Type I IFN receptor signaling and in vitro and in vivo biologic responses caused by type I interferons. The MAR1-5A3 antibody has also been reported to be useful for immunofluorescent staining and flow cytometric analysis, immunoprecipitation and Western blot analysis of IFNAR-1.

Specifications

• Antigen: IFN-a/b Receptor 1
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: MAR1-5A3
• Concentration: 1.0mg/mL
• Conjugate: Unconjugated
• Description: Interferon-alpha/beta Receptor 1; IFN-R-1; Ifar; Ifnar; Ifrc; Infar
• Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
• Host Species: Mouse
• Immunogen: Mouse Ifnar1 extracellular domain DNA
• Purification Method: Affinity Purified
• Quantity: 0.5 mg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Mouse
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG1 κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov