IFN-γ Mouse anti-Human, APC-R700, Clone: B27, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564981
The B27 monoclonal antibody specifically binds to human interferon- γ(IFN- γ). IFN-γis a potent multifunctional cytokine that is produced by several activated cell types including NK, NKT, CD4+TCRαβ+, CD8+TCRαβ+, and TCRγδ + T cells. IFN- γexerts i ts biological effects through specific binding to the high-affinity IFN- γReceptor Complex comprised of IFN- γβ subunits. In addition to its antiviral effects, IFN- γupregulates a number of lymphoid cell functions including the antimicrobial and antitumor responses of macrophages, NK cells, and neutrophils. In addition, IFN- γcan exert strong regulatory influences on the proliferation, differentiation, and effector responses of B cell and T cell subsets. Th ese influences can involve IFN- γ’s capacity to boost MHC class I and II expression by antigen-presenting cells as well as to direct effects on B cells and T cells t hemselves. Human IFN-γis a 14- 18 kDa glycoprotein containing 143 amino acid residues. B27 is a neutralizing antibody. The use of B27 antibody for epitope mapping of human IFN- γhas been described. The B27 antibody has been reported not to bind to denatured IFN- γ.
|IFNG; Interferon-gamma; Interferon-γ; Type II interferon; MAF|
|Human IFN-γ Recombinant Protein|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Aqueous buffered solution containing BSA, protein stabilizer, glycerol and ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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