IFN-γ Mouse anti-Human, Brilliant Violet 711, Clone: 4S.B3, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564793
The 4S.B3 monoclonal antibody specifically binds to interferon-γ(IFN-γ). The immunogen used to generate this hybridoma was partially purified human IFN-γobtained from supernatants of human PBMC stimulated with Staphylococcus aureus . Interferon-γ(IFN-γ) is a potent multifunctional cytokine that is produced by several activated cell types including NK, NKT, CD4+TCRαβ+, CD8+TCRαβ+, and TCRγδ + T cells. IFN- γexerts its biological effects through specific binding to the high-affinity IFN-γReceptor Complex comprised of IFN-γRα (CD119) and ese influences can involve IFN- γ’s capacity to boost MHC class I and II expression by antigen-presenting cells as well as to direct effects on B cells and T cells themselves. Human IFN-γis a 14- 18 kDa glycoprotein containing 143 amino acid residues.
|IFNG; Interferon-gamma; IFG; IFI; Type II interferon|
|Human IFN-γ from supernatants of S. aureus-stimulated PBMC|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Brilliant Violet 711|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Baboon, Cynomolgus, Human, Rhesus|
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