MilliporeSigma™ anti-IGF-IR Clone: αIR3,

Catalog No.	Quantity	Conjugate
GR11L100UG	100 μg	Unconjugated

Catalog No. GR11L100UG Supplier MilliporeSigma™ Supplier No. GR11L100UG

Description

Mouse Monoclonal Antibody

Specifically detects IGF-IR Clone: αIR3 in Human samples, and it is validated for Immunofluorescence, Immunoprecipitation

The insulin-like growth factors (IGFs) or somatomedins are mitogenic peptides present in the plasma of human, rat, and other species. Two distinct but chemically related IGFs have been purified from human plasma: IGF-I (Somatomedin C) and IGF-II. They are single chain polypeptides with molecular weights of 7,640 and 7,471, respectively. Types I and II IGF receptors differ in their structure and in their peptide binding specificity. Type I IGF receptors are structurally homologous to insulin receptors and contain α-subunits (Mr=130,000) that bind peptide, and β-subunits (Mr=90,000), which have intrinsic tyrosine kinase activity. The protein-tyrosine kinase activity of the insulin receptor and, presumably the IGF-I receptor, is required for insulin to stimulate all of its biological responses in cells. Type II receptors are a single polypeptide (Mr=260,000), lack protein-tyrosine kinase activity, and have been shown to be identical to the mannose-6-phosphate receptor.

Specifications

• Antigen: IGF-IR
• Applications: Immunofluorescence, Immunoprecipitation
• Classification: Monoclonal
• Clone: αIR3
• Conjugate: Unconjugated
• Formulation: In 0.05M sodium phosphate buffer, 0.2% gelatin.
• Host Species: Mouse
• Immunogen: partially purified, human placenta IGF-I receptor
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽130kDa α and the ∽90kDa β subunits of IGF-I receptor.
• Target Species: Human
• Content And Storage: 2°C to 8°C
• Form: Purified
• Isotype: IgG1

For Research Use Only