IGF1R alpha Mouse anti-Human, Clone: 2C8, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA110855
MA1-10855 detects IGF-1 Receptor from human samples. MA1-10855 has been successfully used in Western blot applications. The MA1-10855 immunogen is purified human placental IGF-1 receptors.IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of maligt cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.
|PBS with no preservative; pH 7.4|
|CD221, IGFIR, IGFR, JTK13, IGF-I receptor, insulin-like growth factor I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2|
|-20° C, Avoid Freeze/Thaw Cycles|
|Purified human placental IGF-1 receptors.|
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