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IGF1R alpha Mouse anti-Human, Clone: 2C8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA110855

Catalog No. 01-671-868


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Description

Description

MA1-10855 detects IGF-1 Receptor from human samples. MA1-10855 has been successfully used in Western blot applications. The MA1-10855 immunogen is purified human placental IGF-1 receptors.

IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of maligt cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.
Specifications

Specifications

IGF1R alpha
Monoclonal
0.7 mg/mL
PBS with no preservative; pH 7.4
P08069
CD221, IGFIR, IGFR, JTK13, IGF-I receptor, insulin-like growth factor I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3480
Western Blot
2C8
Unconjugated
IGF1R
Liquid
IGF1R
Purified human placental IGF-1 receptors.
Purified
RUO
Antibody
Monoclonal
Human
Documents
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