IkBa Mouse anti-Human, Alexa Fluor 647, Clone: 25/IkBa/MAD-3, BD

Catalog No.	Quantity
BDB560817	50 Tests

Catalog No. BDB560817 Supplier BD Biosciences Supplier No. 560817

Description

Mouse Monoclonal Antibody

NF-κB is a transcription factor that is a member of the mammalian NF-κB/Rel family of proteins. Members of this family are involved in the regulation of cell proliferation, immune function, as well as development.In resting cells, IκBα binds to and maintains NF-κB in the cytoplasm by blocking the nuclear localization sequences of NF-κB. In the cellular response to an extracellular signal, IκBα is phosphorylated and subsequently degraded via the ubiquination-proteasome pathway, allowing NF-κB to translocate to the nucleus. Once in the nucleus, NF-κB can induce the transcription of IκBα thereby renewing the cycle so that IκBα can form a complex with NF-κB and maintain it in its cytoplasmic location. IκBα -/- mice show an increased level of NF-κB activity and have been shown to die soon after birth.

The 25/IkBa/MAD-3 monoclonal antibody recognizes human IκBα regardless of phosphorylation status and does not cross-react with mouse IκBα .

Specifications

• Antigen: IkBa
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 25/IkBa/MAD-3
• Conjugate: Alexa Fluor 647
• Description: MAD-3; I-kappa-B-alpha; IkB-alpha; NFKBIA; NF-kappa-B inhibitor alpha
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Human IκBα aa. 145-302 Recombinant Protein
• Purification Method: Affinity Purified
• Quantity: 50 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG1