IKKγ Mouse, Unlabeled, Clone: C73-764, BD

Catalog No.	Quantity
BDB559675	0.1 mg

Catalog No. BDB559675 Supplier BD Biosciences Supplier No. 559675

Description

Mouse Monoclonal Antibody

The transcription factor NF-κB, (nuclear factor kappa-B) is controlled by interaction with an inhibitory subunit, IκB, which restricts NF-κB to the cytoplasm. Following stimulation by various cytokines or other stimuli, IκB becomes degraded and NF-κB is released to the nucleus. The release of IκB from NF-κB is a critical step in the activation of NF-κB signal pathways. A group of proteins form an NF-κB regulatory complex, or signalsome. Two members of this complex are a pair of closely related serine/threonine kinases, IKKα and IKKβ (aka IKK-1 and IKK-2), which phosphorylate critical residues of IκB, thus targeting it for subsequent degradation. The IKK complex contains similar amounts of IKKα, IKKβ, as well as two other polypeptides, which are differentially processed forms of a third subunit, IKKγ. IKKα and IKKβ become activated following phosphorylation by upstream kinases, including NF-κB-inducing kinase (NIK) and MEKK1. IKKγ interacts preferentially with IKKβ and is required for the activation of the IKK complex. Thus the IKK kinases play an important role in the activation of NF-κB. IKKγ migrates as a doublet between 50-55kDa in SDS-PAGE.

Immunoprecipitation, Western Blotting

Specifications

• Antigen: IKKγ
• Applications: Western Blot
• Classification: Monoclonal
• Clone: C73-764
• Concentration: 0.5mg/mL
• Conjugate: Unconjugated
• Description: NEMO
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Recombinant Human IKKγ
• Purification Method: Affinity Purified
• Quantity: 0.1 mg
• Regulatory Status: RUO
• Research Discipline: Immunology
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG1 κ