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IKKβ w/control Mouse anti-Human, Unlabeled, Clone: F18-1875, BD

Mouse Monoclonal Antibody with Control

Supplier:  BD Biosciences 551920

Catalog No. BDB551920


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Description

Description

HeLa Control Lysate. Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. The nuclear transcription factor kappa-B, NF-κB, is controlled by interaction with an inhibitory subunit, I-κB, which restricts NF-κB to the cytoplasm. Following stimulation by various cytokines or other stimuli, I-κB becomes degraded and NF-κB is released to the nucleus. The release of I-κB from NF-κB is thought to be a critical point in the activation of NF-κB signal pathways. A group of proteins form an NF-κB regulatory complex, or signalsome. Two members of this complex are a pair of closely related serine/threonine kinases, IKKα and IKKβ (also called IKK-1 and IKK-2), which phosphorylate critical residues of I-κB, thus targeting it for subsequent degradation. The IKK complex contains similar amounts of IKKα and IKKβ, as well as two other polypeptides, which are differentially processed forms of a third subunit, IKKγ. IKKα and IKKβ become activated following phosphorylation by upstream kinases, including NF-κB-inducing kinase (NIK) and MEKK1. IKKγ interacts preferentially with IKKβ and is required for the activation of the IKK complex. Experiments done on mice lacking IKKβ demonstrate that these mice died at mid-gestation from uncontrolled liver apoptosis. Furthermore, when cells from IKKβ-deficient m ice were treated with tumor necrosis factor α or interleukin 1, neither IKK nor NF-κB were activated. Thus IKKβ, but not IKKα, plays a pivotal role in the induction of NF-κB and activation of IKK. IKKβ migrates at ∽87kDa in SDS/PAGE. The antibody
recognizes human IKKβ. A recombinant protein corresponding to amino acids 1-666 of human IKKβ was used as the immunogen.

Host Species: Mouse
Clone: F18-1875
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human IKKβ recombinant protein aa. 1-666

Western Blotting

TRUSTED_SUSTAINABILITY
Specifications

Specifications

IKKβ w/control
Monoclonal
0.25mg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human IKKβ recombinant protein aa. 1-666
50 μg
Cell Biology
Human
IgG1
Western Blot
F18-1875
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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