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IL-12 Receptor β2 Hamster anti-Mouse, Unlabeled, Clone: HAM10B9, BD
Hamster Monoclonal Antibody
Supplier: BD Biosciences 552819
Description
The HAM10B9 antibody reacts with the β2subunit (IL-12Rβ2), of the mouse IL-12 receptor complex. The IL-12Rβ2 subunit associates with a β1 subunit to form a heterodimeric IL-12 receptor complex. Each one of the IL-12R subunits exhibits low affinity for IL-12, but in combination, they bind IL-12 with high affinity. The IL-12Rβ1 subunit interacts primarily with IL-12 p40 whereas the IL-12R β2 binds both to IL-12 p40 and IL-12 p35. IL-12Rβ1 is required for high affinity binding of IL-12 but IL-12R β2 is required for signaling. The cytoplasmic regions of the β1 and β2 subunits contain the box 1 and box 2 motifs found in other cytokine receptors such as gp130, LIFR and G-CSFR. Naive T cells do not express IL-12R but both IL-12R subunits can be induced on T cells by antigenic stimulation. The IL12R is also expressed on activated NK cells. Th1 cells express both IL-12R subunits while Th2 cells lose the β2 subunit during differentiation. The HAM10B9 antibody was generated by immunizing hamsters with mouse IL-12Rβ2 transfectants.
Host Species: Hamster
Clone: HAM10B9
Isotype: IgG1 κ
Species Reactivity: Mouse
Immunogen: Mouse IL-12Rβ2 transfectants
Flow Cytometry

Specifications
IL-12 Receptor β2 | |
Monoclonal | |
0.5mg/mL | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
Mouse IL-12Rβ2 transfectants | |
0.1 mg | |
Immunology | |
Mouse | |
IgG1 κ |
Flow Cytometry | |
HAM10B9 | |
Unconjugated | |
Hamster | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at 4°C |
Safety and Handling
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