Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

IL-12 Receptor β2 Hamster anti-Mouse, Unlabeled, Clone: HAM10B9, BD

Hamster Monoclonal Antibody

Supplier:  BD Biosciences 552819

Catalog No. BDB552819


Only null left
Add to Cart

Description

Description

The HAM10B9 antibody reacts with the β2subunit (IL-12Rβ2), of the mouse IL-12 receptor complex. The IL-12Rβ2 subunit associates with a β1 subunit to form a heterodimeric IL-12 receptor complex. Each one of the IL-12R subunits exhibits low affinity for IL-12, but in combination, they bind IL-12 with high affinity. The IL-12Rβ1 subunit interacts primarily with IL-12 p40 whereas the IL-12R β2 binds both to IL-12 p40 and IL-12 p35. IL-12Rβ1 is required for high affinity binding of IL-12 but IL-12R β2 is required for signaling. The cytoplasmic regions of the β1 and β2 subunits contain the box 1 and box 2 motifs found in other cytokine receptors such as gp130, LIFR and G-CSFR. Naive T cells do not express IL-12R but both IL-12R subunits can be induced on T cells by antigenic stimulation. The IL12R is also expressed on activated NK cells. Th1 cells express both IL-12R subunits while Th2 cells lose the β2 subunit during differentiation. The HAM10B9 antibody was generated by immunizing hamsters with mouse IL-12Rβ2 transfectants.

Host Species: Hamster
Clone: HAM10B9
Isotype: IgG1 κ
Species Reactivity: Mouse
Immunogen: Mouse IL-12Rβ2 transfectants

Flow Cytometry

TRUSTED_SUSTAINABILITY
Specifications

Specifications

IL-12 Receptor β2
Monoclonal
0.5mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Mouse IL-12Rβ2 transfectants
0.1 mg
Immunology
Mouse
IgG1 κ
Flow Cytometry
HAM10B9
Unconjugated
Hamster
Affinity Purified
RUO
Primary
Store undiluted at 4°C
Product Suggestions

Product Suggestions

Videos
Safety and Handling

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.

For Research Use Only.