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  6. IL-17A Mouse anti-Human, Alexa Fluor 647, Clone: SCPL1362, BD

IL-17A Mouse anti-Human, Alexa Fluor 647, Clone: SCPL1362, BD

Catalog No. BDB560437 Shop All BD Biosciences Products
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Catalog No. BDB560437 Supplier BD Biosciences Supplier No. 560437
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Description

Mouse Monoclonal Antibody

Human IL-17A, also known as IL-17, is a proinflammatory cytokine that is encoded by the IL17A gene in chromosome 6. IL-17A is produced as a disulfide-linked homodimer comprised of two mature 136-amino acid polypeptides. It is a member of the IL-17 family of structurally related cytokines, designated IL-17A through IL-17F. Activated memory T cells, especially Th17 cells (specialized IL-17A-producing CD4+ T cells distinct from Th1 and Th2 cells) produce IL-17 and provide protective immunity against pathogens. Activated CD8+ T cells, γδT cells, NK cells and neutrophils can also be activated to produce IL-17A. IL-17A binds to and exerts its biological activity through IL-17 receptors (IL-17R) that are expressed by a variety of target cells including fibroblasts, epithelial and endothelial cells, monocytes/macrophages and mast cells. The ubiquitous IL-17R expression pattern may explain the broad tissue responsiveness to IL-17. IL-17 induces stromal cells to secrete cytokines and chemokines involved in inflammatory and hematopoietic processes. For example, IL-17 induces fibroblasts to produce IL-6, IL-8, G-CSF and express increased surface ICAM-1. The SCPL1362 antibody reacts with human IL-17A.

Host Species: Mouse
Clone: O33-782
Isotype: IgG1, κ
Species Reactivity: Human

Flow Cytometry, Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-17A
Applications Flow Cytometry
Classification Monoclonal
Clone SCPL1362
Conjugate Alexa Fluor 647
Description IL-17; IL-17A; CTLA8; Cytotoxic T-lymphocyte-associated serine esterase 8
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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