Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

IL-17A Rat anti-Mouse, Clone: 50101, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523747

Catalog No. PIMA523747


Add to cart

Description

Description

In direct ELISAs, 100% reactivity with Recombinant mouse (rm) IL-17A/IL-17F heterodimer, 50% cross-reactivity with Recombinant human IL-17, and 25% cross-reactivity with Recombinant canine IL-17 is observed. No cross-reactivity with rmIL-17B, rmIL-17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
Specifications

Specifications

IL-17A
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q62386
CTLA8, IL17, interleukin 17, cytotoxic T-lymphocyte-associated serine esterase 8, Interleukin-17A
Rat
IgG2a
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16171
ELISA, Western Blot
50101
Unconjugated
Il17a
Lyophilized
IL17A
E. coli-derived recombit mouse IL-17 Thr22-Ala158
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit