IL-17A Rat anti-Mouse, Clone: 50101, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523747
In direct ELISAs, 100% reactivity with Recombinant mouse (rm) IL-17A/IL-17F heterodimer, 50% cross-reactivity with Recombinant human IL-17, and 25% cross-reactivity with Recombinant canine IL-17 is observed. No cross-reactivity with rmIL-17B, rmIL-17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed. Reconstitute at 0.5 mg/mL in sterile PBS.Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
|PBS with 5% trehalose and No Preservative|
|CTLA8, IL17, interleukin 17, cytotoxic T-lymphocyte-associated serine esterase 8, Interleukin-17A|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|E. coli-derived recombit mouse IL-17 Thr22-Ala158|
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