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  6. IL-17F Mouse anti-Mouse, Alexa Fluor 647, Clone: O79-289, BD

IL-17F Mouse anti-Mouse, Alexa Fluor 647, Clone: O79-289, BD

Catalog No. BDB561657 Shop All BD Biosciences Products
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0.1 mg
25 μg
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BDB561657 25 μg
BDB561630 0.1 mg
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Catalog No. BDB561657 Supplier BD Biosciences Supplier No. 561657

Description

Mouse Monoclonal Antibody

The O79-289 monoclonal antibody specifically binds to the inflammatory cytokine protein, Interleukin-17 (IL-17F). IL-17F is a member of the IL-17 family of cytokines. Among IL-17 family members, IL-17F has the highest amino acid sequence homology to IL-17A. IL-17F is produced by activated CD4+ T helper (Th17) cells, CD8+ T (Tc17) cells and γδ T cells. IL-17F can be secreted as homodimers or as heterodimers with IL-17A. IL-17F and IL-17A have overlapping functions such as inducing epithelial cells and fibroblasts to produce proinflammatory cytokines and chemokines including IL-6, GM-CSF, CXCL1, CCL2, and CCL7. These factors attract and activate neutrophils and other cell types that mediate protective responses against pathogenic microbes or pathologic allergic or autoimmune diseases. IL-17 gene knockout studies have shown that IL-17F and IL-17A have independent functions as well. IL-17F and IL-17A exert their biological function by binding to and signaling through IL-17 receptors comprised of the transmembrane receptor subunits, IL-17RA (CD217) and IL-17RC.

TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-17F
Applications Flow Cytometry
Classification Monoclonal
Clone O79-289
Concentration 0.2mg/mL
Conjugate Alexa Fluor 647
Description Il17f; interleukin 17F; Interleukin-17F
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse IL-17F Recombinant Protein
Purification Method Affinity Purified
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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