MilliporeSigma™ anti-IL-2 Biotin, Clone: JES6-5H4,

Rat Monoclonal Antibody

Supplier:  MilliporeSigma™ MABF1507

Catalog No. MABF1507MI

Description

Specifically detects IL-2 Clone: JES6-5H4 in Mouse samples, and it is validated for Flow Cytometry

The JES6-5H4 antibody binds to mouse Interleukin-2 (IL-2), a 17kDa cytokine that is secreted by activated T cells. This cytokine acts as an autocrine stimulatory factor for T cell proliferation, differentiation and survival, as well as being an effective activator of B cells and inducer of NK cell cytotoxic functions. IL-2 plays a key modulatory role in the differentiation of T cells toward either Th17 or T regulatory (Treg) cell types and is important for Treg cell function. The IL-2 receptor (IL-2R) is a complex consisting of an IL-2R alpha chain (CD25), along with the IL-2R beta chain (CD122) and the common gamma chain (CD132). IL-2 may also bind with low affinity to the T cell surface protein CD25 alone, although this interaction does not induce cell signaling.The JES6-5H4 antibody is extensively used for intracellular detection of IL-2 by flow cytometry, for detection of soluble cytokine in ELISA, and as a neutralizing reagent in vitro and in vivo.

Specifications

• Antigen: IL-2
• Classification: Monoclonal
• Conjugate: Biotin
• Gene Accession No.: P04351
• Host Species: Rat
• Purification Method: Purified by size-exclusion chromatography
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze

• Applications: Flow Cytometry
• Clone: JES6-5H4
• Formulation: Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
• Gene Symbols: Il2, Il-2
• Immunogen: Proprietary immunogen
• Quantity: 25 μg
• Research Discipline: Inflammation, Immunology
• Target Species: Mouse
• Form: Purified

For Research Use Only