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IL-2 Rat anti-Mouse, PE-CF594, Clone: JES6-5H4, BD

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BDB562483 50 μg
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Catalog No. BDB562483 Supplier BD Biosciences Supplier No. 562483
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Description

Rat Monoclonal Antibody

The JES6-5H4 monoclonal antibody specifically binds to mouse interleukin-2 (IL-2). IL-2 is a multifunctional cytokine that plays pivotal roles in immunity and tolerance. It is produced by activated T cells. IL-2 effects the activation, growth, proliferation and/or differentiation of various cell types including T and B lymphocytes and their precursors, LAK cells, NK cells, and monocytes/macrophages. IL-2 mediates its biological activities by binding to IL-2 receptor compleses. The intermediate affinity IL-2R is comprised of IL-2Rβ (CD122) and common gamma chain (γc; CD132) subunits whereas the high-affinity IL-2R is comprised of IL-2Rα (CD25), IL-2Rβ and γc subunits. The JES6-5H4 monoclonal antibody binds to IL-2 and neutralizes its biological activity. This antibody is conjugated to BD Horizon™ PE-CF594, which has been developed exclusively by BD Biosciences as a better alternative to PE-Texas Red™. PE-CF594 excites and emits at similar wavelengths to PE-Texas Red™ yet exhibits improved brightness and spectral characteristics. Due to PE having maximal absorption peaks at 496nm and 564nm, PE-CF594 can be excited by the blue (488nm), green (532nm) and yellow-green (561nm) lasers and can be detected with the same filter set as PE-Texas Red™ (eg 610/20nm filter).

Host Species: Rat
Clone: JES6-5H4
Isotype: IgG2b
Species Reactivity: Mouse
Immunogen: Mouse IL-2 Recombinant Protein

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-2
Applications Flow Cytometry
Classification Monoclonal
Clone JES6-5H4
Concentration 0.2mg/mL
Conjugate PE-CF594
Description Il2; Interleukin-2; T-cell growth factor; TCGF
Formulation Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse IL-2 Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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