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IL-2 Mouse anti-Human, PE, Clone: 5344.111, BD

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BDB340450 50 Tests
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Catalog No. BDB340450 Supplier BD Biosciences Supplier No. 340450

Description

Mouse Monoclonal Antibody

Anti-Human Interleukin-2 (Anti-Hu++IL-2) recognizes a 15- to 18-kilodalton (kd) glycoprotein. IL-2 is primarily synthesized by activated CD4+ T-helper lymphocytes (TH0 and TH1) and also by some CD8+ T lymphocytes. Upon polyclonal or antigenic stimulation, naive T lymphocytes express mainly IL-2. Memory TH1 lymphocytes synthesize IL-2 which mediates (along with other TH1 cytokines) delayed-type hypersensitivity responses. Upon activation, IL-2 is produced and binds to its receptor, resulting in proliferation and differentiation of T, B, and natural killer (NK) lymphocytes. The presence of IL-2 enhances NK-lymphocyte cytotoxicity. IL-2 is also a potent activator of monocytes. Anti-Hu++IL-2, clone 5344.111, is derived from a fusion of Sp2/0 myeloma cells with splenocytes from BALB/c mice immunized with recombinant human IL-2. Anti-Hu++IL-2 is composed of mouse IgG1 heavy chains and kappa light chains.

Host Species: Mouse
Clone: 5344.111
Isotype: IgG1, κ
Species Reactivity: Hu
Immunogen: Human IL-2 protein

Flow Cytometry, Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-2
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone 5344.111
Concentration 1.6μg/mL
Conjugate PE
Formulation Phosphate buffered saline with gelatin and 0.1% sodium azide.
Host Species Mouse
Immunogen Human IL-2 protein
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Isotype IgG1 κ
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