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IL-23 Receptor Rat anti-Mouse, PE, Clone: O78-1208, BD

Catalog No. BDB562497 Shop All BD Biosciences Products
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BDB562497 50 μg
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Catalog No. BDB562497 Supplier BD Biosciences Supplier No. 562497

Description

Rat Monoclonal Antibody

The O78-1208 monoclonal antibody specifically binds to the mouse Interleukin-23 Receptor (IL-23R) subunit that is encoded by the il23r gene. The IL-23R subunit is a type I transmembrane glycoprotein and member of the hemopoietin receptor superfamily. The mouse IL-23 Receptor complex is comprised of IL-23R and IL-12 receptor beta 1 (IL-12Rβ1) subunits. The IL-23R complex can bind IL-23, a cytokine that plays roles in innate and adaptive immunity as well as in autoimmune diseases, eg, by the generation and maintenance of Th17 cells. Mouse IL-23R is expressed by activated/memory CD4+ T cells, Th1, Th2 and Th17 cells, γδ T cells, dendritic cells and macrophages as determined by IL-23R mRNA expression and IL-23R-GFP reporter mouse studies. The IL-23-bound IL-23Rcomplex transduces an intracellular signal pathway mediated by a Jak-STAT signaling cascade.

TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-23 Receptor
Applications Flow Cytometry
Classification Monoclonal
Clone O78-1208
Concentration 0.2mg/mL
Conjugate PE
Description Il23r; IL-23R; Interleukin 23 receptor
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse IL-23 Receptor Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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