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IL-27 p28 Rabbit anti-Human, Invitrogen™

Rabbit Recombinant Polyclonal Antibody

Manufacturer:  Invitrogen 710175

Catalog No. PI710175


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Description

Description

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. Recombit rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombit monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombit antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombit rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.

Interleukin 27, or IL-27 is a cytokine belonging to the IL-12 family. It is a heterodimeric cytokine composed of EBI3 and p28 subunits. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines. IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12R beta2, which in turn suppresses Th2 and Th17 differentiation and proliferation. In humans, the gene is located on the p arm of chromosome 16.
Specifications

Specifications

IL-27 p28
Recombinant Polyclonal
0.5 mg/mL
PBS with 0.09% sodium azide
Q8NEV9
IL-27A, IL27A, IL27p28, IL30, p28, IL-27 p28 subunit, IL-27 subunit alpha, IL-27-A, IL27-A, interleukin 30, interleukin-27 subunit alpha
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
246778
Western Blot
7HCLC
Unconjugated
IL27
Liquid
IL27
Recombit protein corresponding to amino acids 20–189 of human IL-27
Protein A
RUO
Antibody
Oligoclonal
Human
SDS
Documents
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